Phosphodiesterase (PDE) screening is performed with an activity assay format based on the hydrolysis of cyclic AMP and cyclic GMP. Inhibition of PDEs prevents the regulation of these second messengers and was found useful in the treatment of a variety of conditions including pulmonary hypertension, acute refractory cardiac failure, erectile dysfunction, etc.   

# ICE supplies IC50 test and 2 points screening                                                                                     

# Fast turnaround time, 2-3 workdays after recieving samples                                                         

# Please contact us for assay development and custom-tailored screening format