Background: ATPases are essential enzymes that catalyze the hydrolysis of ATP into ADP and inorganic phosphate, a reaction that releases energy necessary for a wide range of cellular processes, including muscle contraction, ion transport, and cellular signaling. Dysregulation of ATPase activity is associated with various diseases, such as neurodegenerative disorders, cancer, and cardiovascular conditions. Targeting ATPases in drug discovery involves developing inhibitors or modulators that can specifically alter ATPase function, with the potential to correct the underlying pathophysiological conditions.
Detection of ATPase Activity: Our ATPase drug discovery service employs the ADP-Glo assay method, a highly sensitive and precise technique for measuring ATPase activity. The ADP-Glo assay works by quantifying the amount of ADP produced during ATP hydrolysis, providing a direct measure of ATPase activity. The assay involves a two-step process: first, the depletion of remaining ATP, and second, the conversion of ADP to ATP, followed by a luminescent detection of ATP. This approach allows for accurate and reliable screening and characterization of potential ATPase inhibitors, making it an ideal tool for advancing drug discovery programs.
Comprehensive ATPase Evaluation Services: Our platform offers a comprehensive range of services for evaluating ATPase activity and the effects of potential inhibitors. We provide detailed analyses of inhibitor potency, selectivity, and mechanism of action across different ATPase targets. Whether you are focusing on a specific ATPase or require a broader panel of targets, our services are designed to meet your needs and support your research objectives in the development of novel therapeutics.
We value your inquiries and are here to provide you with tailored solutions for your drug discovery and development needs. Whether you have questions, require more information, or are interested in discussing potential collaborations, our team of experts is just a message away.
Feel free to reach out to us.