P2X receptors are ligand-gated ion channels, and purinergic receptors are widespread in the nervous system and peripheral tissues, performing a variety of physiological functions: pain generation and modulation, development and regeneration of the nervous system, endothelial cell-mediated vasodilation, regulation of glandular secretion, platelet aggregation, modulation of neuronal, AS, and microglial cell function, immune regulation, inflammatory response, regulation of memory function, and modulation of transmitter release . Purinergic receptors are co-released with a variety of neurotransmitters.

Seven P2X receptor subtypes have been cloned in mammals, all of which are nonselective cation channels that permeate cations such as Na+, K+, and Ca2+ [2-4]. Different subunits exhibit different sensitivities to purinergic agonists and antagonists. Of continuing interest, a number of P2X receptors (P2X2, P2X4, P2X5, and P2X7) exhibit multiple open states in response to ATP, characterized by an increase in permeability to large organic ions and nucleotide-binding dyes over time. P2X receptors are a family of cation-permeable ligand-gated ion channels that open in response to extracellular adenosine 5 '-triphosphate (ATP) binding. They belong to a larger family of receptors called purinergic receptors. P2X receptors are found in a variety of organisms, including humans, mice, rats, rabbits, chickens, zebrafish, bullfrogs, flukes, and amoebas.

The ICE team has built a stable cell line of P2X receptor and completed the in vitro screening model of P2X receptor drugs, which will accelerate the development of new drugs.

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DOI: 10.1038/35058521

DOI: 10.1016/j.ejphar.2013.11.017

DOI: 10.1124/pr.110.003129