Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression and play a critical role in endocrine signaling. With their ligands (usually small lipid molecules, such as steroids, vitamins and fatty acid derivatives) combined with and activate the transcription of the genome, they play different roles in cell differentiation, development, proliferation and metabolism, and are associated with a variety of diseases, such as cancer, cardiovascular disease, inflammation and reproductive abnormalities. This makes it become one of the most important targets for drug development.

ICE provides cell-based NR tests to examine the impact of candidate drugs on nuclear receptor activity.

NR Luciferase reporter Asssay

UAS/GAL4 reporter genes

ARE1/reporter genes

MMTV/reporter genes

ERE/reporter genes

Figure 1. Concentration response curve of ligand in HEK293 cells expressing AR and reporter genes.

ICE is able to provide a fast and efficient compound analysis service to determine the respective excitatory and inhibitory activities, as well as the lead compound selectivity for various drug targets, to help you speed up the compound selection process in hit-to-lead.

NR List