Current progress in the field of KRAS drug discovery is a testament to the power of perseverance and innovation in pharmaceutical research. With ongoing clinical trials and the FDA approval of the first targeted KRAS G12C inhibitor, the landscape of cancer treatment is undergoing a significant transformation. Looking forward, the focus is not only on discovering more selective drugs that target different KRAS mutations but also on understanding the complex biology of KRAS inhibition to circumvent resistance mechanisms and improve patient outcomes. The era of direct KRAS targeting has just begun, and the potential for developing more effective cancer treatments is vast and inspiring.
Two prominent modalities within targeted protein degradation are PROTACs (Proteolysis Targeting Chimeras) and molecular glues. PROTACs function by recruiting an E3 ubiquitin ligase to a target protein, leading to its ubiquitination and subsequent degradation by the proteasome. This strategy enables the degradation of proteins considered "undruggable" by traditional small molecule inhibitors. On the other hand, molecular glues induce protein-protein interactions that result in the degradation of specific targets, providing an alternative approach to PROTACs.
From the initial stages of compound screening to the detailed analysis of drug efficacy and safety, our IVP services integrate seamlessly into the drug development pipeline. Our sophisticated CDX (Cell-Derived Xenograft) models, which include living image cell lines, drug-resistant variants, and gene-edited lines, are meticulously designed to reflect the human biological response to novel treatments. These models serve as critical platforms for testing and refining anti-tumor agents, ensuring that only the most promising candidates move forward in the drug discovery process.
ICE Bioscience provides end-to-end biomarker discovery and detection services designed to accelerate drug development and enhance therapeutic decision-making. From sample collection and processing to biomarker validation and quantification, our advanced platforms and scientific expertise ensure the accurate identification of critical biomarkers. Whether you're in early-stage discovery or clinical development, our services support robust, data-driven insights for drug efficacy, safety assessment, and patient stratification.
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