ATPases are essential enzymes that catalyze the hydrolysis of ATP into ADP and inorganic phosphate. This reaction releases energy required for a wide range of cellular processes, including muscle contraction, ion transport, and cellular signaling. Dysregulation of ATPase activity is associated with diseases such as neurodegenerative disorders, cancer, and cardiovascular conditions.
ICE Bioscience provides ATPase activity assays for the investigation of kinesin motor proteins and VCP-related biology, supporting the evaluation of ATPase inhibitors in discovery-stage research.
Kinesin ATPases are motor proteins responsible for intracellular transport and cell division, particularly during mitosis. Aberrant kinesin expression is linked to dysregulated mitosis in various cancers, making kinesins important therapeutic targets.
VCP (Valosin-Containing Protein), also known as p97, participates in diverse cellular processes, including protein degradation and stress responses. Its association with multiple cancer types makes VCP regulation an important area of therapeutic research.
Our ATPase assay service employs the ADP-Glo technology, a sensitive and precise method for measuring ATPase activity. The assay quantifies the amount of ADP generated during ATP hydrolysis, providing a direct readout of enzymatic activity and enabling the evaluation of potential ATPase inhibitors.
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