Transcription factors (TFs) regulate gene expression and control a wide range of biological processes. Although they have traditionally been challenging drug targets because many lack well-defined binding pockets, their interactions with DNA and multiprotein complexes have become increasingly accessible through advances in screening technologies and computational modeling.
ICE Bioscience supports challenging and historically undruggable targets with biochemical, biophysical, and cell-based assays for evaluating transcription-factor binding, pathway activity, and compound selectivity.
Real-time binding analysis for transcription factors and complexes including STAT proteins and c-Myc.
Fluorescence Polarization assays for ligand-binding analysis, including nuclear receptor targets such as AR.
Proximity-based detection of binding interactions involving STAT proteins, IRF5, and c-Myc/Max/DNA complexes.
Reporter-gene assays, phosphorylated STAT measurements, ELISA, and flow cytometry for pathway and cellular activity analysis.
For dedicated p53 protein, biochemical, biophysical, cell-based, and in vivo model capabilities, visit the p53 Drug Discovery Platform ↗ .
Reporter-gene systems assess transcription-factor activity in living cells by monitoring changes in gene expression.
ELISA, flow cytometry, and related formats quantify phosphorylated STAT proteins as indicators of transcription-factor pathway activation.
We value your inquiries and are here to provide you with tailored solutions for your drug discovery and development needs. Whether you have questions, require more information, or are interested in discussing potential collaborations, our team of experts is just a message away.
Feel free to reach out to us.
Address: Bldg 16, Yd 18, Kechuang 13th St, Etown, Tongzhou Dist, Beijing, 100176, China
Email: marketing@ice-biosci.com
Tel：+86-10-67809840
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