Ion channels play important roles in hormone secretion, gut motility, pain signaling, inflammation, and electrolyte balance. The following targets are relevant to metabolic and gastrointestinal research.
A voltage-gated potassium channel involved in T-cell activation and insulin secretion, making it a potential target for metabolic disorders including diabetes and obesity.
An ATP-sensitive potassium channel essential for pancreatic β-cell insulin secretion and a relevant target for diabetes research.
The Cystic Fibrosis Transmembrane Conductance Regulator controls chloride transport and electrolyte balance, with therapeutic relevance to diarrheal disease and other electrolyte disorders.
A transient receptor potential channel involved in pain perception and inflammation, with relevance to inflammatory bowel disease and other gastrointestinal inflammatory conditions.
A purinergic receptor involved in sensory signaling related to pain and inflammation, with potential relevance to irritable bowel syndrome and inflammatory pain disorders.
An ionotropic serotonin receptor that modulates gut motility and secretion and is relevant to gastrointestinal disorders including irritable bowel syndrome, nausea, and vomiting.
Our metabolic and gastrointestinal portfolio provides an off-target profile of principal ion channels that influence the physiological functions of metabolic and gastrointestinal systems.
The portfolio focuses on channels linked to hormone secretion, gut motility, and electrolyte balance. It supports the identification of selective targets for therapeutic research in metabolic disorders such as diabetes and obesity, as well as gastrointestinal diseases including diarrhea, irritable bowel syndrome, and inflammatory bowel disease.
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