Introduction

The hERG potassium channel, which is voltage-gated in the heart, is key to the rapid delayed rectifier current (IKr) that is crucial for the repolarization phase of the cardiac action potential. The blockage of IKr is often the primary cause of repolarization delay and QT interval prolongation.This situation is linked to a serious heart rhythm disorder known as Torsade de Pointes, which can be life-threatening. Nevertheless, the hERG inhibition can be mitigated by the concurrent inhibition of Nav1.5 (late Nav1.5 current) and Cav1.2.  An disturbance in the Nav1.5 current induced by a drug can also lead to severe arrhythmia Furthermore, the inhibition affecting alternative potassium current sources like Kv4.3, KvLQT1/minK, and Kir2.1 might either intensify or replace hERG inhibition's role in QT interval prolongation.

Cardiac Portfolio

Our cardiac portfolio offers a comprehensive off-target profile of the principal ion channels that have an impact on the duration of the ventricular action potential. The panel also includes profiling for ion channels that are involved in the regulation of heart rate (for example, HCN2, HCN4, Kir3.1/Kir3.4, and Cav3.2), atrial repolarization (Kv1.5), and the body's response to metabolic stress (Kir6.2/SUR2A).

√  Comprehensive CiPA ion channel panel             

√  Beyond CiPA related channels

Plus, some important follow studies are also included in this portfolio to make up an integrated package for the purpose of profiling, risk assessment and MoA research.

√  Action potential assay base on iPS-CMs and rabbit purkinje fiber prep.    

√  Langendorff perfusion assay

√  The surface electrocardiogram assay with guinea pig