The manual patch clamp (MPC) technique has a storied history as a fundamental tool for electrophysiological research since its development in the late 1970s. It is widely used for its unmatched sensitivity and precision, allowing detailed investigation of ion channel behaviors in various cell types. The manual nature of this method provides a level of control and observation that automated patch clamps can't match, particularly when studying complex or rare ion channel pharmacology. This hands-on approach yields high-quality, reproducible data, essential for in-depth functional analyses in drug development and neurophysiological research. Our service harnesses the power of this technique with unmatched expertise, a broad array of targets, and rapid, cost-effective delivery of results.
✅ Proven Expertise: With over 15 years of specialized experience, we've successfully executed thousands of manual patch clamp projects annually.
✅ Extensive Target Range: Our repertoire includes more than 70 ion channel targets, ensuring comprehensive coverage for diverse research needs.
✅ Speed and Value: We guarantee rapid turnaround, delivering precise manual patch clamp data within only 2 weeks, all at an exceptional cost-to-value ratio.
Our cell line-based manual patch-clamp assays offer precise screening with kinetic resolution. We cover key ion channels using validated stable cell lines.
For intracellular targets, our endolysosomal patch-clamp assay enables direct functional recording of channels like TRPML1 in a quasi-native environment.
We offer electrophysiology and functional assays using high-quality primary cells from various species, enabling physiologically relevant drug evaluation.
☑️ Cardiomyocytes – Ventricular and atrial myocytes from mouse, rat, rabbit, and dog
☑️ CNS Neurons – Cortical, hippocampal, and trigeminal ganglion neurons from rat and mouse (adult & neonatal)
☑️ Sensory Neurons – DRG neurons from monkey
☑️ Pancreatic Islet Cells – Islet β-cells from mouse
☑️ Brain Slice Assay – Ex vivo electrophysiological studies in brain slices
Our team delivers high-resolution electrophysiology data, including IC₅₀ curves and kinetic profiles, ensuring accurate compound characterization. With expert consultation and in-depth analysis, we help accelerate decision-making in ion channel and drug discovery.
Learn More About Patch-Clamp in Cardiac Safety
Additional Resources
APPLICATION NOTE:
VX-548's Potent and Selective Inhibition of Nav1.8 Validated by In Vitro Manual Patch-Clamp Analysis
Kv1.3 Inhibition: A Promising Avenue in Immunology and Autoimmune Disease Treatment
Translational Pain Research: Electrophysiological Evaluation of Cynomolgus Monkey DRG Neurons
We value your inquiries and are here to provide you with tailored solutions for your drug discovery and development needs. Whether you have questions, require more information, or are interested in discussing potential collaborations, our team of experts is just a message away.
Feel free to reach out to us.
Address: Bldg 16, Yd 18, Kechuang 13th St, Etown, Tongzhou Dist, Beijing, 100176, China
Email: marketing@ice-biosci.com
Tel：+86-10-67809840
