Introduction

Several ion channels are notably upregulated in cancer cells and play key roles in cancer cell proliferation and tumor growth. These channels are emerging as potential cancer biomarkers, and their inhibition is being explored as a strategy to suppress tumor progression.

Key ion channels linked to cell proliferation include:

    √ Voltage-Gated Potassium Channels (Kv1.3, Kv1.5, hERG1): Upregulated in various cancers,  these channels contribute to cellular processes that support tumor growth.

    √ Voltage-Gated Sodium Channels (Nav1.5, Nav1.7): Promote invasive behavior and metastasis in cancer cells.

    √ Calcium-Activated Potassium Channels (BK, IK): Facilitate cellular signaling pathways that drive proliferation and survival in cancer cells.

Additionally, increased intracellular calcium concentration, driven by calcium influx through specific ion channels, is critical for triggering and sustaining cancer cell proliferation. These ion channels includes:

    √ Voltage-Gated Calcium Channels (Cav1.2, Cav3.2): Mediate calcium entry, promoting proliferation and angiogenesis in tumors.

    √ Transient Receptor Potential (TRP) Channels (TRPC6, TRPM8, TRPV1, TRPV6): Highly expressed in cancer cells, these channels provide significant calcium influx to support cellular growth and survival.

Oncology ion channel Portfolio

Our Oncology Ion Channel Portfolio incorporates many ion channels associated with cancer cell proliferation, providing a valuable tool for therapeutic target discovery. Thus this panel will be powerful tool in the early stages of drug discovery, offering a focused approach to identifying and profiling ion channels that are critical in cancer cell proliferation. By targeting these channels, we can accelerate the development of novel therapeutics with improved selectivity and efficacy.