Oncology Ion Channel Portfolio

Several ion channels are notably upregulated in cancer cells and play key roles in cancer cell proliferation and tumor growth. These channels are emerging as potential cancer biomarkers, and their inhibition is being explored as a strategy to suppress tumor progression.

Key ion channels linked to cell proliferation include voltage-gated potassium channels such as Kv1.3, Kv1.5 and hERG1, which are upregulated in various cancers and contribute to cellular processes that support tumor growth; voltage-gated sodium channels such as Nav1.5 and Nav1.7, which promote invasive behavior and metastasis; and calcium-activated potassium channels such as BK and IK, which facilitate signaling pathways that drive proliferation and survival.

Increased intracellular calcium concentration, driven by calcium influx through specific ion channels, is also critical for triggering and sustaining cancer cell proliferation. Voltage-gated calcium channels such as Cav1.2 and Cav3.2 can mediate calcium entry that promotes proliferation and angiogenesis, while transient receptor potential channels including TRPC6, TRPM8, TRPV1 and TRPV6 can provide calcium influx that supports cancer-cell growth and survival.

Together, these ion channels provide a focused framework for identifying and profiling targets associated with cancer-cell proliferation, survival, invasion and tumor progression.

Oncology Ion Channel Portfolio

Our Oncology Ion Channel Portfolio incorporates ion channels associated with cancer-cell proliferation and provides a focused tool for therapeutic target discovery. The panel supports early-stage drug discovery by enabling the identification and profiling of ion channels that may influence tumor growth, invasion, survival and calcium-dependent signaling.