Our Intact-MS service provides a powerful solution for analyzing the molecular integrity, modifications, and binding interactions of biomolecules in drug discovery. This label-free, high-resolution method is particularly suited for evaluating covalent binding, structural heterogeneity, and post-translational modifications (PTMs), delivering critical data to accelerate your drug discovery pipeline.
Intact-MS operates on the principle of mass spectrometry, which measures the mass-to-charge ratio (m/z) of ions to determine the molecular weight of intact proteins or protein complexes without prior enzymatic digestion. This method preserves the protein's native structure, allowing for a comprehensive analysis of its composition and modifications.
Covalent Binding Analysis: Accurately detect and quantify covalent modifications, including small molecule adducts on target proteins, enabling in-depth characterization of covalent inhibitors.
Post-Translational Modification Assessment: Identify and characterize PTMs such as phosphorylation, glycosylation, and acetylation, providing critical insights into protein structure and activity.
High-Precision Molecular Weight Determination: Obtain reliable measurements of intact protein mass to validate the identity and purity of targets used in drug discovery.
Q Exactive™ Plus Mass Spectrometer
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