Introduction

Ion channels that regulate urinary bladder contractility play a crucial role in maintaining urinary function and are key therapeutic targets for treating urinary incontinence and other genitourinary disorders. These protein complexes are implicated in the pathophysiology of conditions such as overactive bladder and painful bladder syndrome.

    1. Potassium, Calcium-Activated Channels (BK, IK, SK3): These channels regulate urinary bladder contractility and are promising targets for urinary incontinence therapies. BK agonists, which promote bladder relaxation, have been investigated as treatments for overactive bladder.

    2.  Purinergic Receptors (P2X1 and P2X3): These channels contribute to bladder function regulation and are considered potential therapeutic targets for overactive bladder.

    3. Transient Receptor Potential Channels (TRPM8, TRPV1, TRPV4): Found in bladder afferent nerves, these channels are potential targets for managing overactive bladder, painful bladder syndrome, and neurogenic bladder disorders

Genitourinary ion channel Portfolio

Our Genitourinary Ion Channel Portfolio, a targeted screening panel, is designed to identify and profile ion channels critical in the regulation of urinary function and treatment of genitourinary disorders. This panel is a valuable tool in the development of therapeutics aimed at improving urinary health and treating conditions such as urinary incontinence and erectile dysfunction.

The Genitourinary Ion Channel Portfolio is applicable to therapeutic area-specific screenings, including electrophysiology platforms. It allows for the customization of panels to meet specific client needs and is supported by our in vivo and in vitro genitourinary research platform, ensuring translational relevance.