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In Vivo Pharmacokinetic Study

IN VIVO PHARMACOKINETICS

ICE Bioscience is your trusted partner in advancing pharmaceutical innovation through comprehensive in vivo pharmacokinetic (PK) services. Our service portfolio supports whole-body evaluation of candidate compounds throughout the drug development process, helping define exposure, distribution, metabolism, excretion, and safety-related properties.

In vivo pharmacokinetic study workflow
In vivo PK study overview
CONVENTIONAL PK
Conventional PK study service offerings
01 · Species: Mouse, rat, dog, and monkey
02 · Administration Methods: IV, PO, SC, IP, and IM
03 · Dosage Forms: Single, multiple, and cassette dosing
04 · PK Models: Full PK, rapid PK, snapshot PK, and cassette PK
Conventional PK study service offering
PK-RELATED SERVICES
Distribution, excretion, and formulation support
01 · Tissue Distribution and Blood–Brain Barrier Assessment
02 · Excretion and Renal Clearance
03 · Quantitative Detection of Metabolites
04 · Formulation Pretest
BILIARY EXCRETION
In vivo BDC PK
01 · Biliary Duct Intubation Surgery
02 · Metabolic Cage
03 · Bilirubin Determination
04 · Intravenous Infusion
05 · Collection of Bile, Urine, and Feces
06 · Metabolite Identification
07 · Cumulative Excretion Rate
PK AND TOXICITY
PK–toxicity evaluation assays
01 · Evaluate Drug Toxicity
02 · Find a Safe Dose Range
03 · Estimate LD50
04 · Calculate the Linear Regression Equation
05 · Toxicity Observation
06 · Biochemical and Pathological Analysis
PK-toxicity evaluation assays
CNS EXPOSURE
CNS in vivo PK
01 · Cerebrospinal Fluid
02 · Brain Homogenate
03 · Unbound Level in Brain
04 · Dorsal Raphe Nucleus
05 · Hippocampus
06 · Corpus Striatum
07 · Cerebral Cortex
08 · Kpuu
09 · Kp
CNS in vivo PK assessment
TRANSLATIONAL VALUE

In summary, in vivo PK services provide essential data on how drug candidates interact with living systems. These studies support informed decisions about candidate selection, formulation optimization, exposure, distribution, and potential toxicity. The resulting information is critical for advancing drug development pipelines and bringing safe and efficacious medicines toward the market.


Contact Us

We value your inquiries and are here to provide you with tailored solutions for your drug discovery and development needs. Whether you have questions, require more information, or are interested in discussing potential collaborations, our team of experts is just a message away.
Feel free to reach out to us.

We are a CRO service organization, not a hospital




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