In vitro bystander effect assays for ADCs evaluate how cytotoxic payload released by an ADC affects both target antigen-positive (Ag+) cancer cells and neighboring antigen-negative (Ag-) cells.
After release within a targeted cancer cell, payload may diffuse into the surrounding tumor microenvironment and affect nearby cells that do not express the target antigen. Cell-culture and cell-based assays provide insight into this activity and its potential contribution to ADC efficacy.
Assess ADC effects on target cells and surrounding tumor cells to address tumor heterogeneity.
Generate quantitative insight into payload diffusion and cellular impact to support ADC-formulation optimization.
Engineered cell lines and in vivo models support reproducible bystander-effect evaluation.
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