Cardiovascular Ion Channel Portfolio

Introduction

Control of smooth-muscle tension, which is essential for physiological regulation of vascular resistance, involves a wide range of ion channels. These include Ca²⁺-permeable channels such as Cav1.2, P2X4, nAChRα7, and many TRP channels, as well as channels that regulate vasoactive-substance release and arterial tone through control of membrane potential.

The latter group includes K⁺-selective channels such as BK, SK3, IK, Kir2.1, Kir6.1, Kir6.2, Kv1.5, and Kv7.1, together with the non-selective channel TRPM4.

Under pathological conditions including vascular inflammation, chronic hypertension, heart failure, and hypoxia, vascular integrity may decrease, endothelial permeability may increase, and hyperplasia may occur. Ion channels including Kv7.1, nAChRα7, and several TRP channels may contribute to these mechanisms and are therefore relevant to cardiovascular research.

Cardiovascular Ion Channel Portfolio

Our Cardiovascular Ion Channel Portfolio provides an off-target profile of principal ion channels that influence cardiovascular physiology.

The portfolio includes channels that may serve as therapeutic targets for hypertension, atherosclerosis, and heart failure. Because drug-induced dysfunction of these channels may contribute to adverse effects, systematic profiling supports cardiovascular safety assessment and mechanism-of-action research.

Cardiovascular ion-channel assay panel