Helicases are essential enzymes that unwind DNA and RNA duplexes, playing critical roles in processes such as DNA replication, repair, recombination, and transcription. Given their pivotal role in maintaining genomic stability, helicases have emerged as promising therapeutic targets for a range of diseases, including cancer, viral infections, and genetic disorders. Targeting helicases can disrupt these vital processes in pathogens or cancer cells, offering a new approach to treatment. 

Here, we highlight WRN helicase as an example to showcase our capabilities and service offerings.

WRN helicase, a member of the RecQ family, is crucial for DNA replication, repair, recombination, and telomere maintenance. Mutations in WRN lead to Werner syndrome, associated with premature aging and cancer predisposition. Targeting WRN in cancer therapy, particularly in tumors with microsatellite instability (MSI), has shown promising therapeutic potential.

APPLICATION NOTE: Comprehensive WRN Target Capabilities: Proteins, Assays, and In Vivo Resistance Model