| Full Name: | acyl-CoA synthetase long chain family member 5 |
| Gene Name: | ACSL5 |
| Background: | ACSL5 is a member of the long-chain acyl-CoA synthetase family, responsible for catalyzing the conversion of free long-chain fatty acids into fatty acyl-CoA esters. This activation step is essential for fatty acid metabolism, including lipid synthesis and β-oxidation. ACSL5 plays a tissue-specific role in energy homeostasis and is highly expressed in the small intestine and liver. Inhibition of ACSL5 has been shown to reduce fat absorption, modulate gut hormone secretion, and decrease food intake, making it a promising target for obesity and related metabolic disorders. |
| Gene Aliases: | ACS2, ACS5, FACL5, DIAR13 |
| Gene ID: | 51703 |
| Organism: | Human |
| Class: | Ligase / Enzyme |
| Construct Details: | Recombinant, N-terminal GST-tagged |
| Assay Type: | Biochemical |
| Assay Sub Type: | Enzymatic |
| Detection Method: | Fluorescence Intensity (FI) |
Figure: IC50 curve of ACSL5 inhibitor measured by fluorescence intensity assay. Left: Broad ACSL5 inhibitor Triacsin C shows weak inhibition against ACSL5. Right: A patent compound exhibits potent inhibition of ACSL5, demonstrating assay sensitivity and dynamic range.
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2025-09-26
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