Why Induced Proximity?

Induced proximity has emerged as a versatile therapeutic strategy extending far beyond protein degradation. By bringing proteins into spatial proximity through small molecule scaffolds, researchers can now activate, stabilize, sequester, or modulate protein complexes with precision. ICE Bioscience offers comprehensive solutions tailored to these next-generation pharmacologies.

While PROTACs and molecular glues for degradation have dominated the field, non-degradative proximity modalities - such as enzyme activation, signal rewiring, and structural stabilization — are gaining momentum. We support programs targeting both canonical and unconventional proximity mechanisms.

A Case in Point: KRAS Tri-Complex Molecular Glue

One of the most exciting advances in the field is the emergence of tri-complex molecular glues targeting KRAS. By inducing proximity between KRAS and non-canonical effector proteins, these molecules bypass traditional binding pockets and instead create novel interfaces for signaling control. This modality allows for therapeutic intervention in RAS-driven cancers that have resisted conventional inhibitors.

Selective Targeting via RIPTACs

RIPTACs (Regulated Induced Proximity Targeting Chimeras) are bifunctional molecules that selectively kill cancer cells by inducing proximity between a tumor-specific protein and an essential cellular protein. This creates a unique tri-complex that functionally disables the essential protein—but only in cells expressing the tumor marker.

Unlike degradation-based strategies, RIPTACs rely on functional sequestration or mislocalization of the essential protein. This regulated proximity approach enables high tumor selectivity without requiring enzymatic inhibition or catalytic function.

Our Induced Proximity Service Capabilities

✅ Biophysical and biochemical assays for molecular glue and tri-complex agents screening (non-degraders)

✅ Validation of tri-complex proximity agents

✅ Mechanism of action (MoA) profiling and cell-based readouts