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Oncology Ion Channel Portfolio

Introduction

Several ion channels are notably upregulated in cancer cells and play key roles in cancer cell proliferation and tumor growth. These channels are emerging as potential cancer biomarkers, and their inhibition is being explored as a strategy to suppress tumor progression.

Key ion channels linked to cell proliferation include:

√ Voltage-Gated Potassium Channels (Kv1.3, Kv1.5, hERG1): Upregulated in various cancers,  these channels contribute to cellular processes that support tumor growth.

√ Voltage-Gated Sodium Channels (Nav1.5, Nav1.7): Promote invasive behavior and metastasis in cancer cells.

√ Calcium-Activated Potassium Channels (BK, IK): Facilitate cellular signaling pathways that drive proliferation and survival in cancer cells.

Additionally, increased intracellular calcium concentration, driven by calcium influx through specific ion channels, is critical for triggering and sustaining cancer cell proliferation. These ion channels includes:

√ Voltage-Gated Calcium Channels (Cav1.2, Cav3.2): Mediate calcium entry, promoting proliferation and angiogenesis in tumors.

√ Transient Receptor Potential (TRP) Channels (TRPC6, TRPM8, TRPV1, TRPV6): Highly expressed in cancer cells, these channels provide significant calcium influx to support cellular growth and survival.


Oncology ion channel Portfolio

Our Oncology Ion Channel Portfolio incorporates many ion channels associated with cancer cell proliferation, providing a valuable tool for therapeutic target discovery. Thus this panel will be powerful tool in the early stages of drug discovery, offering a focused approach to identifying and profiling ion channels that are critical in cancer cell proliferation. By targeting these channels, we can accelerate the development of novel therapeutics with improved selectivity and efficacy.

 

Protein Assay Table

Ion channel FamilyTargetMethodSpeciesMode
Voltage-gated sodium channelNav1.5Manual patch clamphumanAgonist or Antagonist
Nav1.7Manual patch clamphumanAgonist or Antagonist
Voltage-gated potassium channelKv1.5Manual patch clamphumanAgonist or Antagonist
hERG (Kv11.1)Manual patch clamphumanAgonist or Antagonist
Kv1.3Manual patch clamphumanAgonist or Antagonist
Kv4.2Manual patch clamphumanAgonist or Antagonist
KV3.1Manual patch clamphumanAgonist or Antagonist
KV3.4Manual patch clamphumanAgonist or Antagonist
Voltage-gated calcium channelCav1.2Manual patch clamphumanAgonist or Antagonist
Cav3.2Manual patch clamphumanAgonist or Antagonist
Hyperpolarization-activated channelHCN2Manual patch clamphumanAgonist or Antagonist
HCN4Manual patch clamphumanAgonist or Antagonist
Potassium channel, calcium activatedBKManual patch clamphumanAgonist or Antagonist
IKManual patch clamphumanAgonist or Antagonist
SK2Manual patch clamphumanAgonist or Antagonist
SK3Manual patch clamphumanAgonist or Antagonist
Transient receptor potential channelTRPA1Manual patch clamphumanAgonist or Antagonist
TRPV1Manual patch clamphumanAgonist or Antagonist
TRPV3Manual patch clamphumanAgonist or Antagonist
TRPV4Manual patch clamphumanAgonist or Antagonist
TRPM4Manual patch clamphumanAgonist or Antagonist
TRPM8Manual patch clamphumanAgonist or Antagonist
TRPC5Manual patch clamphumanAgonist or Antagonist
TRPC6Manual patch clamphumanAgonist or Antagonist

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