Target Validation and Assay Development Services

Target validation and assay development are the foundation of every successful drug discovery program. ICE Bioscience provides integrated target validation and custom assay development services that help biotech and pharmaceutical teams confirm target relevance, establish robust screening assays, and generate decision-ready data early in the discovery process.

Target Validation Services

Our scientists support target validation through a combination of biochemical, cellular and biophysical approaches. Services include recombinant protein production, target engagement studies, mechanism-of-action investigation and functional cellular readouts, enabling clients to prioritize targets with confidence before committing to full screening campaigns.

Custom Assay Development

Every target is different. ICE Bioscience designs and optimizes assays tailored to your target class and screening goal, including:

• Biochemical assays (enzyme activity, binding, inhibition)
• Cell-based assays (reporter gene, proliferation, signaling readouts)
• Biophysical assays (SPR, ITC, thermal shift, mass spectrometry)
• Assay transfer, miniaturization and high-throughput adaptation

Why Work with ICE Bioscience

As an integrated drug discovery CRO, ICE Bioscience combines assay development with downstream screening, profiling and DMPK capabilities under one roof. Validated assays are delivered with clear documentation, defined acceptance criteria (such as Z' factor) and reproducible performance to support your hit-finding and lead optimization programs.

If you would like to learn more about this service or discuss your project, please contact our team for a tailored proposal and quotation.