DMPK Cell Line Platform

Cell-based models are essential tools for predicting the absorption, distribution and drug-drug interaction (DDI) potential of new compounds. ICE Bioscience's DMPK cell line platform provides validated transporter and metabolic enzyme cell models that support permeability, efflux and interaction studies in drug discovery.

Available Cell Models

Our DMPK cell line platform includes cell lines engineered or selected for key ADME-relevant functions, supporting assays such as:

• Permeability and efflux ratio assessment (e.g., Caco-2, MDCK-based models)
• Uptake and efflux transporter substrate/inhibition studies
• CYP and metabolic enzyme interaction assays
• Drug-drug interaction risk evaluation

Quality and Validation

Cell models are maintained and validated under standardized conditions, with reference compounds run alongside client samples to ensure data quality and reproducibility. Results are delivered with clear study designs and structured reports.

Integrated DMPK Workflow

The DMPK cell line platform integrates with ICE Bioscience's broader ADME services — including metabolic stability, CYP inhibition and in vivo pharmacokinetics — providing a complete view of your compound's DMPK profile.

If you would like to learn more about this service or discuss your project, please contact our team for a tailored proposal and quotation.