Targeted protein degradation proved a small molecule could eliminate a disease-causing protein instead of blocking it. RIPTACs™, or Regulated Induced Proximity Targeting Chimeras, sit within that same induced proximity category but work differently: a heterobifunctional molecule holds a tumor-specific target protein and a separate, pan-essential effector protein together in a cooperative ternary complex, silencing the essential protein only in cells carrying the target.
Nothing gets degraded. It's a hold-and-kill mechanism, and it's already in patients. An AR-BRD4 RIPTAC™ built on this approach is in a Phase 1/2 trial for metastatic castration-resistant prostate cancer, with meaningful PSA declines reported in patients whose disease had already progressed on prior treatment.
Join Promega and ICE Bioscience in the co-hosted webinar on characterizing a RIPTAC™ mechanism like this one, using an AR-BRD4 system as an example.
Learn how NanoBRET® characterizes the "hold" mechanism by measuring RIPTAC™ ternary complex formation and target engagement in live cells
Explore how an AR-BRD4 case study defines the "kill" response through AR-dependent growth inhibition, together with downstream biomarker modulation
See how a staged in vitro to in vivo assay strategy moves RIPTAC™ candidates beyond mechanistic validation toward developability and translational assessment
Discover how flexible assay development capabilities can accelerate the evaluation of emerging RIPTAC™ and induced-proximity programs

Qing is an International Project Manager at ICE Bioscience, where he leads the development of ICE Bioscience’s Induced Proximity platform, focusing on emerging modalities including RIPTAC, PROTAC, and molecular glue technologies. He has extensive experience in developing biochemical, cellular, DMPK, and in vivo assays to support proximity-based drug discovery programs. Qing holds a Ph.D. in Biology from Tsinghua University and a Master by Research in Biomedical Sciences from the University of Glasgow, with a strong background in targeted protein degradation and molecular biology.

Andrew Zhang is currently the Director of Pharma/Biotech Market Segment at Promega. Prior to joining Promega in 2024, he spent 11 years at AstraZeneca R&D, where he was most recently the Head of Chemical Biology. Over the course of the 11 years at AstraZeneca, Andrew gained experience in cellular target engagement assays, including target deconvolution with mass spectrometry based proteomics. His area of expertise is in the new modes of action being pursued, including targeted protein degradation, induced proximity, and covalent drug discovery. Andrew trained for his PhD at Yale University working at the interface of small molecules and biologics, investigating how to redirect immune response to pathogenic cells, and performed postdoctoral training at the Ontario Institute for Cancer Research in Toronto working on ADCs.
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