Genitourinary Ion Channel Portfolio

Ion channels that regulate urinary bladder contractility play a crucial role in urinary function and are important therapeutic targets for urinary incontinence and other genitourinary disorders. These protein complexes are implicated in conditions such as overactive bladder and painful bladder syndrome.

1. Potassium, Calcium-Activated Channels (BK, IK, SK3): These channels regulate urinary bladder contractility and are promising targets for urinary incontinence therapies. BK agonists, which promote bladder relaxation, have been investigated as potential treatments for overactive bladder.

2. Purinergic Receptors (P2X1 and P2X3): These channels contribute to bladder-function regulation and are considered potential therapeutic targets for overactive bladder.

3. Transient Receptor Potential Channels (TRPM8, TRPV1, TRPV4): These channels are found in bladder afferent nerves and may serve as targets for managing overactive bladder, painful bladder syndrome and neurogenic bladder disorders.

Genitourinary Ion Channel Portfolio

Our Genitourinary Ion Channel Portfolio is a targeted screening panel designed to identify and profile ion channels involved in urinary function and genitourinary disorders. The panel supports the development of therapeutics for conditions such as urinary incontinence and erectile dysfunction.

The portfolio can support therapeutic-area-specific screening through electrophysiology platforms. Panel configurations can be customized to meet specific research needs and are supported by our in vivo and in vitro genitourinary research capabilities to promote translational relevance.