ICE Bioscience Posters

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In the past 50 years, obesity has become an international public health issue that affects the quality of life, increases the risk of illness, and raises health-care costs in countries in all parts of the world. Anti-obesity drugs will be the most impactful trend of 2024, followed by personalized and precision medicine, immuno-oncology drug development, real-world evidence and cell and gene therapies. Research all over the world has been carried about around multiple anti-obesity targets on different mechanism like genetic, epigenetic, physiological, behavioural, sociocultural, and environmental factors.

Here we briefly introduced our Biology Building Blocks platform which including the target, assay and technology for Cannabinoid Receptor 1 (CB1), the Apelin receptor (APJ) and G Protein-Coupled Receptor 75 (GPR75), which are all related to anti-obesity pathway with different mechanisms. This study described the recombinant protein purification, cell line generation, functional assay development and application. Meanwhile, several CDX modes are constructed for promisingly conducting in-vivo experiments and biomarker detection. Combine with small molecules library, Al/ML and MedChem collaboration, our Bioscience platform may accelerate drug discovery process.