The PARP (Poly(ADP-ribose) polymerase) family consists of enzymes vital for cellular functions, notably DNA repair, crucial for genomic stability. Once malfunction, these enzymes can contribute to various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. PARP inhibitors (PARPi), which target these enzymes, have shown promise as treatments for certain cancers, particularly those with DNA repair pathway defects such as BRCA-mutated cancer. Here, we have developed and validated PARP-related biochemical assays, cell-based assays, drug resistant cell line construction, and in vivo pharmacology models to support novel PARPi discovery.
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