High-throughput screening cell panel is very important tool in drug research and development, the tested sensitive cell lines can provide references for in vivo models or indication for the selection of clinical trial subjects. Cell Panel screening can be used to study the mechanism of action and selectivity of drugs, and combined with bioinformatics studies can help researchers discover biomarkers of drug response. Moreover, Cell Panel screening can be used to study whether combination therapy strategies improve cancer treatment effect and solve clinical drug resistance and other problems.
The Human RAS Oncogenes play a vital role in cancer development, including KRAS, NRAS and HRAS, KRAS is the most frequently mutated RAS isoform with a mutation incidence of >10% across all cancers, and up to 70% and 20% in pancreatic and non-small cell lung cancer (NSCLC), respectively.
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