Lysine acetyltransferase 6A (KAT6A, also called MOZ and MYST3) is a histone acetyltransferase (HAT) belonging to the MYST family. Other members include MOF(KAT8)、MORF(KAT6B)、TIP60(KAT5) and HBO1(KAT7). The histone substrates of KAT6A identified to date include H3K9, -K14, and -K23. KAT6A has been reported to play a critical role in hematopoietic stem cell maintenance, cell cycle regulation, and cell senescence. In addition, KAT6A is thought to be an oncogene in human cancers, including breast cancer, glioma and leukemia. Here, we have developed KAT6A related biochemical assays, cellular assays and in vivo pharmacology models to support novel KAT6A inhibitor discovery.
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