ICE Bioscience Posters

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Androgen Receptor (AR) belongs to the steroid receptor subfamily of the nuclear receptor superfamily. As a transcription factor, AR is responsible for regulating the physiological effects of androgens, such as testosterone and dihydrotestosterone (DHT), plays a pivotal role in the initiation and advancement of prostate cancer (PCa) and breast cancer (BC), with therapeutic approaches primarily focusing on the modulation of the AR signaling pathway.

We constructed an integrated experimental cascade, including biochemical and cell-based assays to conduct the high throughput hit-to-lead compound screening. Meanwhile, CDX modes are constructed for promisingly conducting in-vivo experiments and biomarker detection. Thus, ICE supports multiple approaches for helping the drug discovery and development of AR to facilitate the treatment of PCa and BC.