ICE Bioscience Posters

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Intrinsic immunity is an important line of defense against pathogenic microorganisms, which can effectively fight and remove external dangers. However, dysfunction of innate and adaptive immunity is considered to be a key step in the initiation and maintenance of autoimmune diseases. NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a multimeric protein complex, which can detect exogenous pathogen irritants and endogenous danger signals, which promote interleukin (IL)-1β and IL-18 secretion and pyroptosis mediated by caspase-1. Numerous studies have shown their significance in autoimmune diseases, such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), which strongly indicate that NLRP3 inflammasome complex may serve as a promising and novel therapeutic target for clinical treatment in inflammatory-related diseases.