Microsatellite Instability (MSI) is a condition characterized by the presence of mutations in microsatellite regions of DNA, which can lead to the accumulation of mutations in these re- gions and result in genomic instability. This phenomenon occurs in various cancer types. Werner helicase (WRN) plays a crucial role in highly MSI (MSI-H) cancer cells, causing syn- thetic lethality when WRN is inhibited or knocked out. Previous studies have revealed that WRN inhibitors, such as HRO761 and VVD-214, can effectively kill MSI-H cancer cells, includ- ing human colorectal cell lines HCT116 and SW48.
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