The KRAS protein is a signaling molecule associated with various types of cancer. Due to its high mutation rate and critical role in tumor development, KRAS has become an important target for anticancer drug development. However, because the KRAS protein lacks traditional small-molecule binding pockets, it has long been considered an "undruggable" target. In recent years, Molecular Glue technology has provided a new approach for targeting KRAS by inducing or stabilizing protein-protein interactions (PPls).
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