| Full Name: | Calcitonin receptor |
| Gene Name: | CALCR |
| Background: | CALCR encodes the calcitonin receptor (CTR), a Class B (secretin-family) GPCR that binds peptide ligands and activates intracellular signaling via G proteins. Quantitative biophysical binding measurements can support hit confirmation and lead optimization by characterizing target engagement across diverse chemotypes, including peptides and non-peptide modalities. SPR provides label-free, real-time binding data and enables affinity determination under controlled assay conditions. |
| Gene Aliases: | CTR; CT-R; |
| Gene ID: | 799 |
| Organism: | Human |
| Class: | Class B GPCR (Secretin family) |
| Target/Construct Info: | Recombinant human CALCR preparation suitable for SPR; assay format can be configured for capture or immobilization depending on project needs. |
| Assay Type: | Biophysical |
| Assay Sub Type: | Surface Plasmon Resonance (SPR) |
| Detection Method: | Label-free, real-time binding response (RU) with steady-state affinity fitting |
| Application: | Quantitative affinity characterization of customer compounds against CALCR (hit confirmation, SAR support, lead optimization) |
| Features: | This assay determines binding affinity using a steady-state SPR model based on equilibrium responses (Req) across an analyte concentration series. |
| Typical Readouts: | Sensorgrams (RU vs time), steady-state fit, KD (affinity), Rmax (fit parameter) |
Figure: Representative SPR data for CALCR using a reference peptide for assay validation. Left: sensorgrams across a concentration series. Right: steady-state affinity fitting based on equilibrium responses.
2026-01-15
2025-09-26
2025-09-25
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