| Full Name: | Amylin receptor subtype 3 (AMY3 receptor; CTR/RAMP3 complex) |
| Target Name: | AMY3R (CALCR + RAMP3) |
| Background: | The AMY3 receptor is a functional receptor complex formed by the calcitonin receptor (CTR; encoded by CALCR) and receptor activity-modifying protein 3 (RAMP3; encoded by RAMP3). RAMP association modulates receptor pharmacology and ligand recognition, making AMY receptor complexes important targets for quantitative binding characterization. SPR provides label-free, real-time binding measurements that support affinity ranking and SAR evaluation of customer compounds against AMY3R. |
| Component Genes: | CALCR (CTR) + RAMP3 |
| Gene IDs: | CALCR: 799; RAMP3: 10267 |
| Organism: | Human |
| Class: | Class B GPCR complex (CTR + RAMP) |
| Target/Construct Info: | Recombinant human AMY3R preparation (CTR/RAMP3 complex) suitable for SPR; assay configuration can be adjusted based on project requirements. |
| Assay Type: | Biophysical |
| Assay Sub Type: | Surface Plasmon Resonance (SPR) |
| Detection Method: | Label-free, real-time binding response (RU) with steady-state affinity fitting |
| Application: | Quantitative affinity characterization of customer compounds against AMY3R (hit confirmation, SAR support, lead optimization) |
| Features: | This assay determines binding affinity using a steady-state SPR model based on equilibrium responses (Req) across an analyte concentration series. The workflow includes reference subtraction to control for non-specific binding and can support different surface strategies (capture or immobilization) to help preserve target activity. |
| Typical Readouts: | Sensorgrams (RU vs time), equilibrium responses (Req), steady-state fit, KD (affinity), Rmax (fit parameter) |
Figure: Representative SPR data for immobilized AMY3R using a reference compound (Cagrilintide) for assay validation.
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