ICE Bioscience provides ion channel drug-screening services across more than 100 targets. Our platform combines stable cell-line development, functional assay expertise and experience with challenging targets to support discovery and safety programs.
Studies can be conducted in primary cells, iPSC-derived differentiated cells, stable transfected cell lines and transiently transfected cells, enabling an assay strategy matched to the biology of each program.
Manual Patch Clamp (MPC) ↗ supports high-resolution, single-cell current recording and detailed electrophysiological characterization.
Voltage-gated and ligand-gated channel profiling. QPatch and related automated systems provide efficient electrophysiological screening where throughput is important.
Functional ion-flux readouts. FLIPR-based measurements can monitor intracellular calcium or potassium-related responses in real time.
Cell-based membrane-potential assays. Flexible functional readouts support screening of channel activation and modulation.
Ion-channel profiling can help assess both compound efficacy and potential off-target risk. Our services are designed to support research at different stages of drug discovery and safety assessment.
Assay conditions are optimized to support stable and repeatable data.
Experienced teams support both established and challenging channel targets.
Assay protocol development and custom services can be tailored to program needs.
Manual patch clamp, automated patch clamp and FLIPR assays accommodate precision and throughput requirements.
Target profiling can assess potential efficacy as well as off-target activity. For example, hERG potassium-channel inhibition is an important consideration in cardiac safety assessment.
Manual patch clamp remains a reference technique for recording single-cell currents. Our established workflow supports timely data delivery for screening programs.
Automated patch clamp enables higher-throughput compound screening while extending electrophysiology studies beyond the throughput of traditional manual techniques.
Monitor real-time membrane-potential changes associated with ion-channel activation and ion-transporter proteins.
Measure calcium flux and functional activity of ligand- and voltage-gated potassium channels, including global intracellular calcium responses following channel activation.
FLIPR supports compound screening in 96- or 384-well plate formats for efficient functional assessment.
We value your inquiries and are here to provide you with tailored solutions for your drug discovery and development needs. Whether you have questions, require more information, or are interested in discussing potential collaborations, our team of experts is just a message away.
Feel free to reach out to us.
Address: Bldg 16, Yd 18, Kechuang 13th St, Etown, Tongzhou Dist, Beijing, 100176, China
Email: marketing@ice-biosci.com
Tel：+86-10-67809840
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