Ion Channel Selectivity Profiling Panels

Ion channels are essential for the electrical activity of excitable cells and also play critical roles in non-excitable tissues. They are important targets in conditions including cardiac rhythm disorders, hypertension, pain, stroke, epilepsy, depression, bipolar disorder, chronic obstructive pulmonary disease (COPD), autoimmune disease, and diabetes. Ion channels are also important in drug development as therapeutic targets and biomarkers for evaluating drug safety.

During drug discovery, determining compound specificity through selectivity profiling and safety assessment is essential. Many drugs withdrawn from the market because of cardiac adverse effects were found to block the human ether-à-go-go-related gene (hERG) ion channel.

ICE Bioscience provides more than 100 validated ion-channel stable cell lines organized into therapeutic-area portfolios. Our screening services include manual patch clamp, automated patch clamp, and FLIPR assays for selectivity profiling, risk assessment, and mechanism-of-action research.

ICE Bioscience Ion Channel Profiling Panels

Download the Target List ↗