Ion channels are essential for the electrical activity of excitable cells and play critical roles in non-excitable tissues as well. They are key targets for treating a variety of medical conditions, including heart rhythm disorders, high blood pressure, the effects of local anesthetics, pain relief, stroke mitigation, epilepsy, mood disorders like depression and bipolar disorder, chronic obstructive pulmonary disease (COPD), autoimmune conditions, and diabetes. Their importance extends to drug development, where they serve not only as targets for new medications but also as essential biomarkers for evaluating drug safety.
In the drug discovery process, pinpointing a compound’s target specificity through selectivity profiling and conducting safety assessments are vital steps. Many drugs withdrawn from the market due to cardiac-related adverse effects have been shown to block the human ether-a-go-go (hERG) ion channel.
ICE Bioscience boasts an extensive array of validated assays for profiling the selectivity of ion channels. Our comprehensive ion channel suite encompasses more than 100 stable cell lines, meticulously categorized into different portfolios in alignment with the latest scientific insights. We are equipped to deliver a spectrum of ion channel screening services, ranging from manual patch clamp to automated patch clamp and FLIPR assays, tailored to therapeutic areas for profiling, risk assessment, and mechanism of action (MoA) research.
ICE Bioscience Ion Channel Profiling:
▶ Cardiovascular Profiling Panel
▶ Pain-Inflammation Profiling Panel
▶ Seizure-Convulsion Profiling Panel
▶ Metabolic GI Profiling Panel
▶ Neurodegeneration/Stroke Profiling Panel
▶ Pulmonary-Respiratory Profiling Panel
▶ Psychiatric Disorder Profiling Panel
▶ Genitourinary Profiling Panel
We value your inquiries and are here to provide you with tailored solutions for your drug discovery and development needs. Whether you have questions, require more information, or are interested in discussing potential collaborations, our team of experts is just a message away.
Feel free to reach out to us.
