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Neurodegeneration/Stroke Ion Channel Portfolio

Introduction

Several ion channels implicated in central and peripheral nervous system disorders, including ischemic stroke, Alzheimer’s disease, and multiple sclerosis. These channels represent critical therapeutic targets for neuroprotection, reducing neuronal damage, and managing neurodegenerative symptoms.

 

Neurodegeneration/stroke ion channel Portfolio

Our neurodegeneration/stroke ion channel portfolio is a curated collection of ion channels that have been implicated in the treatment and etiology of neurodegenerative diseases and stroke. This panel is designed to assess a compound's target specificity and potential off-target effects, which is crucial for the discovery of drugs that can effectively manage neurodegenerative conditions and stroke-related complications.

The Neurodegeneration/Stroke Ion Channel Portfolio is a powerful tool in the early stages of drug discovery, offering a focused approach to identifying and profiling ion channels that are critical in neurodegenerative and stroke-related conditions. By targeting these channels, we can accelerate the development of novel therapeutics with improved selectivity and efficacy.


Protein Assay Table

Ion channel FamilyTargetMethodSpeciesMode
Voltage-gated sodium channelNav1.1Manual patch clamphumanAgonist or Antagonist
Nav1.2Manual patch clamphumanAgonist or Antagonist
Nav1.3Manual patch clamphumanAgonist or Antagonist
Nav1.6Manual patch clamphumanAgonist or Antagonist
Voltage-gated potassium channelKv1.1Manual patch clamphumanAgonist or Antagonist
Kv1.2Manual patch clamphumanAgonist or Antagonist
Kv1.3Manual patch clamphumanAgonist or Antagonist
Kv1.5Manual patch clamphumanAgonist or Antagonist
Kv2.1Manual patch clamphumanAgonist or Antagonist
Kv3.4Manual patch clamphumanAgonist or Antagonist
KCNQ2/3Manual patch clamphumanAgonist or Antagonist
Potassium channel, calcium activatedIKManual patch clamphumanAgonist or Antagonist
SK1Manual patch clamphumanAgonist or Antagonist
SK2Manual patch clamphumanAgonist or Antagonist
Ligand-gated ion channelNR1/NR2AManual patch clamphumanAgonist or Antagonist
NR1/NR2BManual patch clamphumanAgonist or Antagonist
NR1/NR2CManual patch clamphumanAgonist or Antagonist
NR1/NR2DManual patch clamphumanAgonist or Antagonist
nAChR α7/RIC3Manual patch clamphumanAgonist or Antagonist
Chloride channelCFTRManual patch clamphumanAgonist or Antagonist
Acid-sensing ion channelASIC1aManual patch clamphumanAntagonist
Potassium channel, inward rectifierKir6.2/Sur1Manual patch clamphumanAgonist or Antagonist

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