Two prominent modalities within targeted protein degradation are PROTACs (Proteolysis Targeting Chimeras) and molecular glues. PROTACs function by recruiting an E3 ubiquitin ligase to a target protein, leading to its ubiquitination and subsequent degradation by the proteasome. This strategy enables the degradation of proteins considered "undruggable" by traditional small molecule inhibitors. On the other hand, molecular glues induce protein-protein interactions that result in the degradation of specific targets, providing an alternative approach to PROTACs.
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