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DNA Damage Response & Synthetic Lethality

DNA Damage Response and Synthetic Lethality

Targeting DNA damage response (DDR) pathways and exploiting synthetic lethality are important strategies for developing novel cancer therapies. DDR maintains genomic integrity by detecting and repairing DNA damage; when these pathways are compromised, cells can become reliant on alternative repair mechanisms.

ICE Bioscience supports DDR and synthetic-lethality drug research from protein expression through in vivo models, enabling identification and validation of therapeutic targets for cancer drug discovery.

Key Capabilities
Connected Support for DDR Drug Discovery
01
Extensive Protein Products

More than 60 validated recombinant proteins related to DDR and synthetic lethality.

02
Biochemical and Biophysical Platforms

More than 10 assay formats, including ADP-Glo, HTRF, FP, and SPR, supporting hundreds of ready-to-use DDR-targeting assays.

Key targets include WRN ↗, PARP ↗, CDK ↗, POLQ ↗, PARG ↗, PKMYT1, PRMT5 ↗, and p53 ↗.

03
Specialized Cell Lines and Cell-Based Assays

Diverse cell-line collections, including knockout and drug-resistant variants, supporting viability, biomarker, and reporter assays.

04
Custom In Vivo Models

Tailored in vivo models developed specifically to support DDR research.

DDR Integrated Drug Discovery Services
DDR integrated drug discovery services
Resource
DDR Service Capabilities Brochure

Download our brochure to explore ICE Bioscience’s comprehensive DDR drug-discovery capabilities.

Download Brochure ↗

Contact Us

We value your inquiries and are here to provide you with tailored solutions for your drug discovery and development needs. Whether you have questions, require more information, or are interested in discussing potential collaborations, our team of experts is just a message away.
Feel free to reach out to us.

We are a CRO service organization, not a hospital




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