Lysine Acetyltransferases (KATs)

Lysine acetyltransferases (KATs) are an important class of enzymes responsible for acetylating lysine residues on histones and other proteins. This modification contributes to gene-expression regulation, protein function, and chromatin dynamics. Dysregulated KAT activity has been implicated in cancer, neurodegenerative disorders, and inflammatory conditions.

Targeting KATs with selective inhibitors may help modulate abnormal acetylation patterns and restore disease-relevant cellular functions.

KAT Inhibition Assay

ICE Bioscience uses TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) technology to detect the inhibitory effects of small molecules on KAT activity. This sensitive and specific approach monitors changes in acetylation activity and supports accurate, reproducible evaluation of potential KAT inhibitors.

Comprehensive KAT Target Assays

Our platform supports assays for a broad range of KAT targets involved in gene regulation, chromatin remodeling, and disease biology.

HAT1

GCN5

CREBBP

P300

TIP60

MOZ

MORF

MYST2

MYST1

These target assays support assessment of KAT inhibitor potency and selectivity across different enzyme subtypes, helping guide the development of targeted therapeutic strategies.

KAT target assay platform

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Target Based Assays

Lysine Acetyltransferases (KATs)

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