ICE Bioscience Posters

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The characterization of biomolecular interactions is fundamental to drug discovery, particularly for complex modalities such as small molecules, molecular glues (MG), and PROTACs. This study presents a comparative analysis of several key biophysical technologies, with a focus on the innovative DIANTHUS platform.

DIANTHUS combines Spectral Shift-based detection with Time-Resolved Immuno-FRET (TRIC) to deliver superior performance in homogeneous assays. Compared to established techniques like HTRF and SPR, DIANTHUS demonstrates exceptional sensitivity, a broad dynamic range, and remarkable resilience to compound interference. These attributes make it an ideal solution for challenging applications, including the high-throughput screening and precise mechanistic study of molecular glues and PROTACs, which function by inducing or stabilizing protein-protein interactions. Our findings position the DIANTHUS platform as a powerful and versatile tool for accelerating the development of next-generation therapeutic agents.