SPR Services

Biophysical assays directly detect drug-target binding and occupy a special position in drug discovery. At ICE Bioscience, our biophysical experts develop assays for diverse targets using a range of technologies, with surface plasmon resonance (SPR) as a primary platform.

SPR enables real-time monitoring of molecular interactions and supports determination of equilibrium dissociation constant K_D, association rate constant k_a, and dissociation rate constant k_d. As a widely used standard for molecular-interaction analysis, SPR supports multiple stages of pharmaceutical research and development.

Our SPR assays combine label-free and high-throughput screening with comprehensive kinetic studies and precise affinity measurement across diverse applications.

Figure 1. SPR Assay Principle. When plane-polarized light encounters a metal film under conditions of total internal reflection, it initiates the SPR phenomenon. SPR signal intensity is directly influenced by the refractive index of the medium surrounding the sensor chip.

ICE Bioscience offers customized SPR services and a continuously expanding portfolio of more than 100 ready-to-use SPR assays.

Custom SPR services are designed and optimized around your specific targets and research needs. Our pre-developed assay catalog provides immediate access to reliable, validated assays to help save time and resources.

The nuclear enzyme poly(ADP-ribose) polymerase (PARP) contributes to DNA repair following DNA damage. We use SPR to assess the selectivity and binding affinity of PARP inhibitors. PARP enzymatic assays, PARP trapping assays, and PARP panel screening services are also available.

Figure 2. SPR result showing the selectivity of PARP inhibitor AZD5305.