EEG recording captures brain electrical activity in intact animals, adding an objective physiological measure to preclinical CNS pharmacology. ICE Bioscience uses model-specific recording and analysis strategies to investigate electrographic seizures, sleep-wake patterns and responses to candidate compounds.
Depending on the research question, EEG can be paired with EMG for sleep staging or evaluated alongside behavioral observations in seizure studies.
Cortical recordings and recordings from defined sites, including the hippocampus, support analysis of seizure-related electrical activity. Multi-region EEG is available for studies that require a broader view of brain activity.
Seizure studies can be designed around wired PowerLab acquisition or wireless DSI telemetry, according to the model and recording requirements.
EEG and EMG recordings provide complementary signals for classifying wakefulness, non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep in rodents.
EEG or ECoG recording can be incorporated into maximal electroshock, intraperitoneal PTZ, intra-hippocampal kainic acid, amygdala kindling and acute febrile seizure studies. Model-specific recording is combined with behavioral assessment when appropriate.
EEG/EMG supports baseline and post-treatment sleep monitoring in normal rodents and pharmacologically induced sleep-disturbance paradigms, including corticosterone-treated mice and PCPA-treated rats. Cage-change studies assess transient disruption caused by an unfamiliar environment.
Review seizure-like discharges using model-appropriate measures such as onset latency, event frequency and duration, raw traces and time-frequency displays.
Quantify sleep latency, time spent awake or in NREM and REM sleep, and the frequency and duration of sleep-wake episodes.
In seizure programs, EEG findings can be interpreted alongside seizure scores and protection outcomes. Study endpoints and observation windows are selected to fit the model and pharmacological question.
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